Sessions

14 March 2019 Start 13:00 hours

Session 1:

Adipocyte-Brain Crosstalk

The brain has a fundamental role in the regulation of energy homeostasis, exerting a rigorous control on body weight, appetite, and energy expenditure. Since the discovery of leptin and other adipokines, peripheral organs such as adipose tissue have gained equal importance in the regulation of obesity.

This session covers different aspects of the pathophysiology of obesity, including the close relationship between the brain and the adipose tissue.

Keynote speaker: Ana Domingos, Oxford

 

Session 2:

Clocks in conflict: how time of feeding matters

Our central master clock, the suprachiasmatic nucleus (SCN), is synchronized by the 24-hour rhythm of light and darkness and communicates this information to various clocks throughout the body. However, the timing of food intake is able to regulate clocks in the periphery, particularly in metabolically active tissues, independent of the SCN.

This session focuses on the crosstalk of peripheral and central clocks in obesity, and the physiological consequences that derive from circadian conflict and desynchronization.

Keynote speaker: Andries Kalsbeek, Amsterdam

 

Poster Presentation in the evening

 

Dinner and get-together

 

15 March 2019 End 16:00 hours

Session 3:

The Neurovascular Unit in Obesity: It’s not all about neurons

The neurovascular unit is central to the delivery of cytokines, nutrients, and oxygen to the brain. Several different cell types interact to modulate the homeostatic balance in the central nervous system, which in turn mediates a number of feeding and reward related behaviors.

This session will pay special attention to the non-neuronal cell types in the neurovascular unit, focusing on endothelial cells and astrocytes, and how they may in turn regulate neuronal activity and behavior related to obesity.

Keynote speaker: Cristina García Cáceres, Munich 

 

Session 4:

Beyond the hypothalamus: novel targets in obesity

The hypothalamus is classically defined as the main brain area for the control of energy balance, regulating both energy intake and energy expenditure. However, a growing body of evidence is suggesting the previously unknown involvement of other brain regions, as well peripheral signals, in the regulation of energy homeostasis and obesity.

This session focuses on novel regions, compounds, and mechanisms in the regulation of energy balance, and in the development and maintenance of obesity.

Keynote speaker: Karolina Skibicka, Gothenburg

 

Session 5:

BAT: The right kind of fat

Brown adipose tissue (BAT) is known to be the main site of adaptive thermogenesis in mammals, acting to maintain core body temperature by burning metabolic substrates. Boosting energy expenditure by stimulating BAT activity seems to be promising as therapeutic strategy to tackle obesity and metabolic abnormalities. However, several aspects on molecular mechanism controlling energy expenditure and BAT activation are still unclear.

This session aims to further elucidate BAT physiology and function as well as mechanisms involved in thermogenesis and energy metabolism, with a special focus on the neuroendocrine pathways controlling cold-induced BAT activity.

Keynote speaker: Camilla Charlotte Schéele, Copenhagen