Effects of subchronic activation of BAT in humans

Project Description:

Brown adipose tissue (BAT) is a highly specialized type of fat tissue showing potential metabolic benefit on glucose and lipid metabolism when activated. However, metabolic effects and pathways of subchronic BAT activation in everyday life is not sufficiently characterized to date. This project aims at studying BAT activity in health and disease and its consecutive effects on human glucose and lipid metabolism.


Experimental Methods:

  • Clinical experimental study setting, working with healthy normal-weight/obese human subjects and patients with type 2 diabetes
  • Metabolic phenotyping (intraveneous glucose tolerance testing, hyperinsulinemic euglycemic clamp procedure, body composition by BIA and whole body plethysmography)
  • Hormone analytics
  • Lipidomics
  • Clock gene expression and microRNA profiles