Neural underpinnings of neurostimulation induced weight gain in Parkinson’s disease

The purpose of the applied project is to investigate neural indices of body mass (BM) gain in patients with Parkinson’s disease (PD) after deep brain stimulation (DBS) of the subthalamic nucleus (STN). For this, a multimodal and multidimensional study investigating clinical, behavioral, imaging and neurophysiological alterations within the same sample of PD patients will be used. The role of brain-periphery crosstalk will be assessed to answer the question how neuronal network alterations drive BM changes in PD patients after STN DBS, which will give further insights into the underlying pathophysiological mechanisms.


  • Hartmut Niekisch, Julia Steinhardt, Julia Berghäuser, Sara Bertazzoni, Erika Kaschinski, Jana Kasper, Martin Kisse, Jessica Mitlöhner, Jeet Singh, Judith Weber, Renato Frischknecht, Max Happel. Learning induces transient upregulation of brevican in the auditory cortex during consolidation of long-term memories, The Journal of Neuroscience, 39 (36), 7049-7060, 2019.
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  • Julia Steinhardt, Thomas F Münte, Sebastian M Schmid, Britta Wilms, Norbert Brüggemann. A Systematic Review of Body Mass Gain after Deep Brain Stimulation of the Subthalamic Nucleus in Patients with Parkinson’s Disease, Obesity Reviews, 21(2), 1-14 2019.
  • Jan Uter, Marcus Heldmann, Berenike Rogge, Martina Obst, Julia Steinhardt, Georg Brabant, Carla Moran, Krishna Chatterjee, Thomas Münte. Performance monitoring in patients with mutations of the thyroid hormone beta-receptor: an electro-physiological study. NeuroImage: Clinical, Vol 26, 1-7 2020.