Canceled! CBBM Lecture "Obesity and brain insulin resistance- cause or consequence"

by Prof. Dr. Hans-Ulrich Häring,

Department of Internal Medicine IV,

University of Tübingen

will take place on Tuesday, December 13, 2016 from 17:15 to 18:15 hours in CBBM Research Building, EG, Room 50/51.

Host: Prof. Hendrik Lehnert
Department of Internal Medicine I
Universität zu Lübeck


The Tübingen family study collects people with increased risk to develop type 2 diabetes and comprises by now approx. 3.000 deeply phenotyped individuals. We used wholebody MRI imaging to assess bodyfat distribution patterns. We could identify subphenotypes of bodyfat distribution, a metabolically healthy phenotype of obesity (MHO) versus a metabolically unhealthy phenotype (MUHO) as well as distinct patterns of perivascular adiopose tissue as well as neckfat.

In a subgroup of approx. 250 individuals we studied brain insulin effects by MEG and fMRI and observed brain insulin resistance in obese people. We used nasal insulin as a tool to study brain effects in the fMRI.

Stimulation of brain insulin signalling by nasal insulin caused brain responses related to homeostatic regulation, eating behaviour but also caused changes of peripheral insulin sensitivity as determined by glucose clamp. Based on stable isotope techniques this brain derived signals affect both glucose appearance from the liver as well as glucose disappearance. Low hypothalamic insulin sensitivity correlated with increased visceral fat and decreased subcutaneous fat. We hypothesize that the brain insulin resistance causes unfavourable fat distribution patterns as a consequence of impaired signalling from the brain to the periphery favouring accumulation of visceral fat. This mechanism might also favour the develoment of NAFLD.



Present Position:

Head of the IVth Medical Department, University of Tübingen

Chair of Internal Medicine, Endocrinology, Diabetes, Angiology, Nephrology and Clinical Chemistry

1986-1996: Head of the Clinical Experimental Department, Institute for Diabetes Research and Oberarzt, IIIrd Medical Department of the Schwabing City Hospital

1983 - 1986: IIIrd Medical Department of the Schwabing City Hospital and Institute for Diabetes Research

1982-1983: Post doctoral fellowship at the Joslin Diabetes Research Laboratories, Harvard Medical School, Boston

1977-1981: Institute of Diabetes Research, Munich


2016 Von Mering Medaille

2015 Claude Bernard Lecture

2014 Member of the National Academy of Science Leopoldina Germany

2011 Hellmut Mehnert Award , together with Prof. Dr. Errol Morrison

2010 Dr. h.c. of the University of Athens2010

2008 Paul Langerhans award of the German Diabetes Association

1989 Oskar Minkowski award, European Association for the Study of Diabetes

1986 Bertram price of the German Association for Diabetes research


1992 Professor of Internal Medicine, Ludwig-Maximilians Universität, München

1986 "Habilitation" thesis, Ludwig-Maximilians Universität, München

1978 MD thesis, Ludwig-Maximilians Universität, München
MD degree obtained in 1976, Ludwig-Maximilians Universität, München


Hirsch (h) Factor: 81


Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke, 2002 - 2010 (Leibniz-Institut)

Robert-Bosch Foundation, 2002 – 2010

School of Clinical Medicine, University of Cambridge, Addenbrookes Hospital, since 2008

Deutsches Diabetes Zentrum, Düsseldorf, SAB since 1998-2015, chair since 2002-2013 (Leibniz-Institut)

Co-chair of the Deutsches Zentrum für Diabetesforschung (Helmholtz-Institut)

Member of the Scientific Committee of the International Symposia on Insulin Receptor and Insulin Action” since 1990


Study dean of the University of Tübingen, 2002 - 2006